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Arylia contains the active substance Denosumab with a protein structure. Denosumab is a human monoclonal antibody (lgG2) that targets and binds with high affinity and specificity to RANKL.

patient information leaflet

  • Arylia

Arylia

Arylia

Arylia  contains the active substance Denosumab with a protein structure. Denosumab is a human monoclonal antibody (lgG2) that targets and binds with high affinity and specificity to RANKL. RANKL is a protein which is necessary for the formation, function and survival of osteoclast (the cell for bone resorption). Arylia stops RANKI from activating its receptor, RANKL, present on the surface of osteoclasts. This prevents osteoclast formation, function, and survival, hence decreasing resorption of bone and increasing bone mass and strength.

Bone is a living tissue that is constantly regenerating. Estrogen (female hormone) helps keep bones strong and healthy. Estrogen levels in the body decrease after menopause and causes weak and brittle bones which ultimately leads to osteoporosis. Men can also be leaded osteoporosis due to certain factors, such as aging and low levels of Testosterone (male hormone) cause osteoporosis. This problem is also found in people taking estrogen and testosterone inhibitors to treat breast and prostate cancer.

Arylia is used to treat

  • Osteoporosis in postmenopausal women and in men at increased risk of fractures.
  • Bone loss associated with hormone ablation in men with prostate cancer at increased risk of fractures and bone loss in females receiving aromatase inhibitor therapy for breast cancer.
  • Bone loss associated with long-term systemic glucocorticoid therapy in adult patients at increased risk of fracture.

How to use Arylia

Always take this medicine exactly as your doctor prescribed .The recommended dose is one pre-filled syringe of 60 mg administered once every 6 months, as a single injection under the skin (subcutaneous). You should also take calcium and vitamin D supplements while being on treatment with Arylia. Your doctor will discuss this with you.

 

 

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More